Kyosuke Kosaka, a normal seventeen-year-old high-school student, hasn't gotten along with his younger sister, Kirino, in years. For longer than he can remember, Kirino has ignored his comings and goings and looked at him with spurning eyes. It seemed as if the relationship between Kyosuke and his sister, now fourteen, would continue this way forever. One day, however, Kyosuke finds a DVD case of a magical girl anime entitled Hoshikuzu Witch Meruru (Stardust Witch Meruru), which had fallen into the entranceway of his house. To Kyosuke's surprise, inside the case, an adult video game entitled Imoto to Koishi yo! (Love with Little Sister!) is hidden. After finding out that Kirino was the the owner, She confesses her love for little Sisters anime/eroge to him. Will Kyosuke keep her secret? or will Kirino turn her brother into an otaku too.